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In another study, COVID-19 patients exhibited a reduced total antioxidant capacity but higher levels of antioxidant enzymes (superoxide dismutase and catalase) and markers of oxidative cell damage (carbonyl and lipid peroxidation) compared to controls, indicating an imbalanced redox status in these individuals [148]
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Those effects were absent in mice lacking NNMT, which supports the enzyme as the target (Kannt et al., 2018)
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