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To investigate the role of KEAP1 in NACET-dependent expression, we transduced ARPE-19 cells with lentiviral particles for the expression of shRNAs targeting the 3′UTR of KEAP1 mRNA or GFP (as a negative control)
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it suppresses cytokine production of T lymphocytes in cells and has been shown to do the same in patients with rheumatoid arthritis
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