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Independent work from the Evans laboratory confirmed the gain-of-function counterpart: a 2023 study by Xia, Scholtes, Dufour, and colleagues in Molecular Metabolism showed that genetic activation of ERRα in mouse skeletal muscle drove myofiber aerobic transformation — increased oxidative myofibers, angiogenesis, mitochondrial biogenesis, and fat oxidation — and enhanced running endurance and fatigue-resistance without exercise training
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