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Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling - ScienceDirect
In parallel, alcohol-induced zinc deficiency dampens activation of the anti-oxidant response element by decreasing the expression and nuclear binding of its master transcription factor, Nrf2
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Activating both at full dose simultaneously, with no titration runway, is what community sources describe as the failure mode that drives discontinuation
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