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When glucose oxidation increases, acetyl groups can be translocated from acyl-CoA within the mitochondrial matrix to the cytoplasm

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It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends.¹² The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing.¹² Metabolic loss tracks weight regain