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However, in the context of dysbiosis, tryptophan is preferentially metabolized via the kynurenine pathway through activation of IDO, leading to the accumulation of neuroactive metabolites such as quinolinic acid, which acts as an NMDA receptor agonist and exerts neurotoxic effects, and kynurenic acid, which functions as an NMDA antagonist with neuroprotective properties (146)
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