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Most of the facts repeated about it — the picomolar HGF binding affinity, the comparison against BDNF, the mechanism itself — trace back to four papers from a single laboratory, and two of those four were retracted in April 2025 after an institutional investigation found falsified data

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TB-500 contains the active sequence of thymosin beta-4, notably the central LKKTETQ domain, identified as the primary motif responsible for the protein's biological activity on cell migration and tissue repair