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Due to its dependency on SAM as a cofactor, it is evident that NNMT plays a key role in maintaining the SAM:SAH ratio, often referred to as the “methylation index”, which is indicative of the hyper- or hypo-methylation of histones in cells [58]
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630,631 NADP + has been demonstrated as an endogenous inhibitor of PARPs, which extend the therapeutic effect of PARP inhibitors on cancers with higher levels of NADP +
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