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Folate and nucleic acid metabolism The figure highlights that riboflavin in the form of flavin adenine dinucleotide (FAD) is a required cofactor for the enzyme methylenetetrahydrofolate reductase (MTHFR), which reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate
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Ascorbate is present in millimolar concentrations in plant and mammalian cells, although the latter are often deficient when grown in cell culture (Chepda et al
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