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It is possible to determine the fractional stoichiometry of phosphorylation sites on a large scale by using ratios observed in both the phosphopeptide, its non-phosphorylated counterpart peptide and the respective protein between treatment conditions from SILAC data 25 and TMT-multiplexed data 24,26

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This is a key differentiator from naturally occurring amylin, which has a shorter duration of action

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