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OPA1, whose cleavage is dependent on MFN2, is linked to changes alterations in mitochondrial metabolism and is implicated in the regulation of cristae morphology, respiratory efficiency, and the formation of respiratory chain supercomplexes in mice [49]

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However, “homeostasis” (i.e., in the stomach as stomach cytoprotection/adaptative cytoprotection, and in the other organs as organoprotection) still warrants eventual realization in more advanced practice (providing that prostaglandins analogues have no more than marginal application in gastroduodenal lesions therapy)

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