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In addition to release of PRR ligands, hepatocyte stress and death are associated with release of pro-inflammatory cytokines, including inflammasome-mediated interleukin-1β (IL-1β), which further contributes to NASH-associated hepatitis (171)
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The receptors for these signaling molecules are typically protein kinases, belonging to one of two broad classes: serine/threonine kinases and tyrosine kinases
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