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Tirzepatide, a 39-amino-acid dual GIP/GLP-1 receptor agonist, is supported by extensive clinical data for metabolic conditions, including type 2 diabetes and obesity

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Nature · 10.1038/nature13198 View source ↗ Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ · 2017 Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Journal of medicinal chemistry · View source ↗ Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ · 2018 Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice Biochemical pharmacology · View source ↗ Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ · 2019 Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle Biochemical pharmacology · View source ↗ Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ · 2021 Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice Scientific reports · View source ↗ Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D · 2021 Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies Journal of pharmaceutical and biomedical analysis · View source ↗ Akar S, Duran T, Azzawri AA, Koçak N, Çelik Ç, Yıldırım Hİ · 2021 Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · View source ↗ Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, Watowich S · 2022 Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice Scientific reports · View source ↗ Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H · 2024 Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction Diabetes, obesity & metabolism · View source ↗ Customer reviews Efficient and fast order fulfillment, helpful support, and—most importantly—they provide very reliable and comprehensive CoA documentation