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The strategy needs to provide incentives for private sector investment, supported by government provision of essential public goods, including infrastructure, education, healthcare, clean water and electricity and telecommunications

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Most of these Nrf2 activators affect Nrf2 activity by modifying intermolecular disulfide bonds between two Keap1 molecules at Cys273 and Cys288, to stabilize and enhance nuclear accumulation of Nrf2.66 For instance, sulforaphane induces the transcription of phase II enzymes, while inhibits phase I enzymes expression and facilitates cancer cell apoptosis via p53 mechanisms.67 Additionally, sulforaphane targets NF‐κB68 as well as both JUN and FOS of the AP‐1 complex to perform an anti‐inflammatory effect.69 Another well‐studied chemopreventive drug, synthetic oleanane triterpenoids, inhibits carcinogenesis through the suppression of oncogenes transcription as diverse as K‐Ras, TP53, Brca1 , and Erbb2 in many organs such as pancreas, breast, or lung.70, 71 Indeed, many drugs that function by enhancing the Nrf2 activity are now in clinical trials for numerous indications