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Given these multiscale findings, spatiotemporal level changes in brain GSH and other antioxidants may indicate that certain brain regions, in particular, metabolically expensive hub regions (e.g., posterior cingulate cortex) (Badhwar et al., 2017, Tomasi et al., 2013), are more vulnerable to aging-related OS (Badhwar et al., 2017, Hahn et al., 2022, Tomasi et al., 2013)