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Compared to tissue specimens of BVZ-sensitive GBM patients, BVZ-resistant ones had a decreased MIF expression and an increased TAM infiltration (248)

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Areas Needing Further Investigation Long-term safety profile in healthy adults (currently entirely uncharacterized beyond 12-month elderly data) Cancer incidence with sustained IGF-1 elevation (no adequate long-term data) Counter-regulatory mechanisms in humans and their implications for sustained research protocols Pharmacokinetics in renal impairment (a registered trial exists but published outcomes were not available in reviewed literature) Combination effects when used alongside selective androgen receptor modulators (community data suggests serum lipid disruption, but no peer-reviewed characterization exists) MK-677 Regulatory and Research Status FDA Status MK-677 is not approved by the FDA for any human therapeutic indication

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