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Indeed, there is a strong association between AKI, CKD, and ESKD (113–115), as it has been demonstrated that both single and repetitive episodes of AKI significantly increase the risk for developing CKD in youth and adults with diabetes (116–120), aminoglycoside usage (121), and sepsis (77), and this occurs to a greater degree in individuals with vs

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This can produce a functional undermethylation pattern without assuming that every patient simply needs more methyl donors