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[49] (2022) investigated NNMT function in adipocytes and reported two key findings: (1) NNMT knockdown reduced lipid accumulation and TG content, accompanied by decreased expression of adipogenic transcription factors (PPARγ, CCAAT/enhancer-binding protein alpha [C/EBPα], SREBP1) and lipid metabolism genes— Fabp4 (fatty acid-binding protein 4 [FABP4]), Fasn (fatty acid synthase [FASN]), Slc27a1 (FATP1, SLC27A1)
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