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D-Nle-X-Ile-NH-(CH 2 )5-CONH 2 derivatives were found to compete with Hinge for HGF binding and exhibited a range of affinities for HGF, with ¾s ranging from 1.37xl0 ~7 - 1.33xl O " '°M (Figure 23)
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Other lines of evidence were also taken into consideration when the Q-value exceeded 0.01, such as if the metabolite shares a common pathway with a highly significant compound, or if the metabolite is in a similar biochemical functional family with other significant compounds
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