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For instance, a large-scale cohort study from the CoLaus|PsyCoLaus project (N = 3459) revealed that antibodies against Fusobacterium nucleatum , a common oral pathogen, were significantly associated with an increased risk of cardiovascular events ( phyla Proteobacteria , Firmicutes , and Bacteroidetes in blood circulation which could be colonized in the gastrointestinal tract, was associated with cardio-metabolic diseases ( Veillonella in the gut might aggravate hypertension ( 2 The oral and gut microbiota: composition and functional crosstalk 2.1 Oral microbiota landscape The oral cavity, composed of the anterior lip, the lateral cheek, the floor of the inferior mouth, the posterior oropharynx, the superior palate and characterized by its unique microenvironment with varying pH levels, oxygen concentrations, and nutrient availability, harbors a highly diverse microbial community ( Firmicutes and Bacteroidetes constituting the dominant phyla ( Streptococcus spp

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