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The core mechanism underlying the interplay between ferroptosis and pyroptosis is as follows: mitochondrial damage-associated molecular patterns released during ferroptosis, such as mitochondrial DNA and ROS, can be recognized by the NLRP3 inflammasome, leading to caspase-1 activation and subsequent cleavage of gasdermin D to form plasma membrane pores, thereby executing pyroptosis and releasing mature IL-1β and IL-18 (73–76)