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It has been found that mutations in the amyloid protein precursor ( APP ), presenilin-1 ( PSEN1 ), and presenilin-2 ( PSEN2 ) genes are associated with autosomal dominant early-onset familial AD, while apolipoprotein E4 ( APOE4 ) represents the most significant genetic risk factor for late-onset sporadic AD, contributing to the deposition of Aβ peptides and hyperphosphorylated tau proteins (Giau et al., 2019
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