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In addition, withaferin A (WA), a natural ferroptosis inducer in NB, activates Kelch-like ECH-associated protein 1 to activate the nuclear factor-like 2 pathway and produces increased intracellular unstable Fe(II) levels after heme oxygenase-1 is excessively activated, inducing ferroptosis or inactivating GPX4 (109)
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A deficiency in omega-3 PUFAs is associated with inflammation and lipid peroxidation in depression (161)
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