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NMN and NR are the most used and both have shown an increase in NAD + levels in the cell (Nikiforov et al., 2011) (Table 2)

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Despite the development of derivatives like N-acetylcysteine amide and N-acetylcysteine ethyl ester which offer improved cell uptake efficiency, bioavailability and antioxidant performance compared to NAC, their application potential for bone tissue engineering warrant further exploration due to the reduced oxidative stability and limited ability to counteract cysteine toxicity (Tosi et al., 2021