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Lack of Human Clinical Data The most significant limitation is the extremely limited published human clinical trial data: Minimal peer-reviewed human studies available in international journals No large-scale Phase I, II, or III trials registered in international databases Human safety profile inadequately characterized Optimal human dosing protocols undefined Long-term human effects completely unstudied Most research originates from a single institution in Russia, with limited independent validation by international research groups
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Although GLS inhibition is effective in hematologic and some solid cancers, PDAC displays adaptive metabolic networks that sustain proliferation during GLS inhibition and rarely shows any beneficial therapeutic effects
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