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10 Unlike traditional antidepressants that take weeks to alter mood, esketamine demonstrates that modulating the NMDAR can produce rapid, sustained antidepressant effects within hours in patients who have failed multiple previous therapies with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)
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However, here are some general guidelines: For individuals with a B12 deficiency, a common protocol may involve a daily dosage of 1,000 mcg for one week, followed by the same dosage once weekly, and then once per month after addressing the deficiency
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