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In MS, GSH metabolism is impaired in regions of the CNS that have been demyelinated and correlates with mitochondrial dysfunction and axonal injury ( 2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass
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Glitazones, the major PPAR-agonist, decreases glucose but not TGs
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