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This may be rapid activation of the bypassing loop that occurs in the rat with infrarenal occlusion of the inferior vena cava (and thereby, resolved Virchow), much like in the rats with ischemic/reperfusion colitis, duodenal venous congestion lesions, perforated cecum, bile duct ligation induced liver cirrhosis and portal hypertension ( 31 - 33 , 42 , 57 )
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Its upregulation is significantly associated with poor patient prognosis (77)
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