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METALLURGY C07—ORGANIC CHEMISTRY C07D—HETEROCYCLIC COMPOUNDS C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms C07D215/10—Quaternary compounds C—CHEMISTRY

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In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation