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Among these 77 miRNAs, 24 were reported to be differentially expressed in human CRC also ( Table 3 ), highlighting that the identified signature was relevant for human disease ( in vitro studies demonstrated that miR-139-5p overexpression led to a remarkable reduction in CRC cell migration and invasion, without affecting cell proliferation ( A screening of 939 miRNAs highlighted, with respect to the above profiling studies, the downregulation of miR-195 and miR-497 and the upregulation of miR-424 in CRC tissues with respect to non-cancerous mucosa ( in vitro in CRC cell lines observing reduced proliferation, cell survival, migration and invasion
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