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276 engineered a novel polyethylene terephthalate (PET) hydrolase MG8 variant MG8(S171pDAP), conjected with a split GFP system, by replacing catalytic serine residue (S171) of MG8 with its isosteric amino analogue pDAP
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[7] So the honest one-line summary is that both build on GLP-1 but recruit a different second pathway — amylin for CagriSema, GIP for tirzepatide — and there is a further structural difference underneath that: CagriSema achieves its dual action with two separate peptides, while tirzepatide achieves its dual action with one
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