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Glutathione peroxidase‐1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice - Chu - 2020 - Aging Cell - Wiley Online Library
Chronic inflammation, driven by immune cell infiltration (macrophages, T cells, B cells) and pro-inflammatory cytokines (IL-1β, TNF-α, IL-6), activates signaling pathways such as NF-κB and MAPK, promoting disc cell apoptosis and extracellular matrix (ECM) degradation (Figure 1)
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[DOI] [PubMed] [Google Scholar] 102.Manickam D.S., Brynskikh A.M., Kopanic J.L., Sorgen P.L., Klyachko N.L., Batrakova E.V., Bronich T.K., Kabanov A.V
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