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Rofecoxib is a selective COX-2 inhibitor, which was evaluated in clinical trials for acute GA, and it was reported to reduce the expression of inflammatory mediators, such as IL-6, and alleviate patient pain by inhibiting COX-2-regulated AA metabolism (211)
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as well as Virani et al., who did not report any differences in global DNA methylation, could be explained by specific type of cells (CD34 + cells) used in the analysis by Almgren et al
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