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nucleatum fusiforme , Treponema denticola , Bacteroides Loescheii , Porphyromonas gingivalis , Bacteroides inermedius and Peptostreptococcus micros , are capable of metabolizing L-cysteine or degrading glutathione to form hydrogen sulfide (H 2 S) within the periodontal pocket, which is toxic to mammalian cells by inactivating cytochrome oxidase, and is also reported to inhibit the catalase.[5,34] Mäkinen and Mäkinen[131] reported the presence of enzyme GGT (that breaks down glutathione to Cys-Gly in human cell membrane) in the outer cell envelope of T