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One interesting result of these experiments was that, regardless of neuronal activity state, the reaction fluxes associated to the glutamine flux from astrocytes to neurons, as well as the glucose uptake and the glycolytic activity, did not present a significant variation due to an observed depletion of glutamate (Glu), Aspartate (Asp) and glutamine (Gln) in astrocytes and an accumulation of these metabolites in the neuron