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1 Introduction DM is characterized by chronic and persistent hyperglycemia and causes macrovascular and microvascular complications, which is a major cause of end-stage renal disease, blindness, and amputation today ( The development and progression of DM has complex pathophysiological mechanisms, with inflammation, autophagy dysregulation, oxidative stress, and hemodynamic dysregulation all involved in the progression of the disease ( 2 Oxidative stress and ROS The concept of oxidative stress was first introduced by the German scientist Helmut Sies and refered to the imbalance of oxidants and antioxidants that can cause damage to the organism ( Structurally, free radicals are highly reactive substances containing at least one unpaired electron and are active derivatives of ROS and reactive nitrogen species (RNS), which are closely associated with the initiation of oxidative stress ( Figure 1 )

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