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For example, a null hypothesis could be “there is no difference in the incidences of postextubation respiratory failure in obese patients treated with NIV compared to standard care.” On the other hand, an alternate hypothesis could be “the use of NIV reduces the incidence of postextubation respiratory failure in obese patients.” Based on the study hypothesis, RCTs can be classified into 3 types: superiority, non-inferiority, and equivalence trials (Table 2)

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