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371 In HIV-associated nephropathy, LPA–LPAR1/3 signaling modulates glomerular and tubular epithelial cells by activating NF-κB, increasing the expression of fibrotic markers such as α-SMA, CTGF, fibronectin, and collagen I, which is accompanied by the phosphorylation of key effectors such as PI3K, Akt, p38 MAPK, ERK, ILK-1, and FAK, driving renal nephropathy and fibrosis
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