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Infection with arginase-deficient parasite in C57BL/6 mice increased PD-1-directed clonal exhaustion leading to impaired IFN-γ production (200), suggesting that parasite-specific arginase mitigates T cell exhaustion, thereby enabling the maintenance of M2 macrophage polarization
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FMT is also a promising treatment strategy for ME/CFS, as there are indications that the microbiome may have an enormous influence on the disease, particularly its neurological symptoms [94]
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