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The phosphatidylinositol 3-kinase (PI3K)/AKT and Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathways were hindered, and the p38-MAPK pathway was promoted under these conditions, resulting in G1 phase arrest and autophagy in the osteoblast cell line MC3T3-E1 ( 3.3 Effects of Iron Overload on Manifestations of Synovial Lesions Mediated by Various Cell Types OA is a degenerative inflammatory disease, leading to multiple joint and peri-joint damage (Robinson et al., 2016)