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Thiosulfate formed from H 2 S through mitochondrial oxidation can undergo reduction and thus recycling by an enzymatic process dependent on dihydrolipoic acid (the reduced form of lipoic acid).105 While most H 2 S oxidation occurs within mitochondria, extra-mitochondrial oxidation occurs by reactive oxygen species and reactive nitrogen species.106 Thus, tissue concentrations of H 2 S can be expected to be lower in more oxidative environments

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