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Disorders Associated with Defective Tyrosine Metabolism Defects in three of the enzymes of tyrosine catabolism result in increased concentrations of tyrosine and metabolites in the blood and urine
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The “Four-parameter combined model”, consisting of MDA+ PP–13 + PAPP-A+ B-HCG, demonstrated a sensitivity and specificity of 97% and 75% in the prediction of preeclampsia in the first trimester [77]
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