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The combination of hyperpigmentation, macrocytic hyperchromic anemia, pancytopenia, and low Vitamin B12 levels was indicative of megaloblastic anemia secondary to Vitamin B12 deficiency
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However, As 3+ , despite being an inducer of oxidative stress, induced GCLC transcriptional activity by a mechanism that is independent of Nrf1 or Nrf2 [87]
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