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In some sarcoidosis centers glucocorticoids are used as a bridge with concomitant weaning until steroid-sparing agents reach efficacious doses ( Approaches to systemic treatment The ERS guidelines and a recently published Delphi consensus statement from a large group of worldwide sarcoidosis experts advocate an approach to therapy that balances the use of reduced doses of corticosteroids with the (early) stepwise addition of steroid sparing anti-inflammatory non-biologic and biologic agents ( The proposed approach to corticosteroid use is to limit continuation to a 3–6 month period to allow for demonstration of therapeutic response (46–48)

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The primary site of GPS metabolism is the liver, where cytochrome P450 enzymes play a significant role in its biotransformation, resulting in the generation of diverse metabolites ( 6 Toxicity and safety Research into the acute toxicity of GPS in animal models, including mice and rats, indicates that GPS exhibits a relatively low level of acute toxicity

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