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For example, melatonin supplementation has been found to increase the expression of genes such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and pentraxin 3 (PTX3) ( In addition to its effects on gene expression, melatonin influences the production of steroid hormones by granulosa cells
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Furthermore, oxidized galectin‐1 in SLE patients fails to bind the inhibitory receptor VSTM1, leading to increased ROS levels in neutrophils, which in turn increase NET formation and inflammation [80]
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