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Frontiers | Editorial: Gut permeability-related endotoxemia and cardiovascular disease: A new clinical challenge

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Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-α, and IL-1β, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype (97)