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Advanced Symptoms Advanced neuropathy symptoms may include: Loss of protective sensation Difficulty walking Muscle weakness Foot drop Frequent falls Open sores or ulcers Severe burning pain Loss of balance Muscle wasting Autonomic dysfunction Red Flag Symptoms Seek urgent evaluation when neuropathy symptoms include: Rapidly progressive weakness Loss of ability to walk Paralysis Severe back pain with neurological deficits Loss of bowel or bladder control Sudden one-sided weakness Facial drooping Trouble speaking New neuropathy after chemotherapy or toxin exposure Rapidly spreading numbness or weakness Ascending symptoms that move from your feet upward – Guillain-Barré syndrome What Causes Peripheral Neuropathy