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Doses Per Vial 5mg vial: At 2.5mg/week = 2 weeks At 5mg/week = 1 week 10mg vial: At 2.5mg/week = 4 weeks At 5mg/week = 2 weeks At 7.5mg/week = 1.3 weeks At 10mg/week = 1 week 15mg vial: At 2.5mg/week = 6 weeks At 5mg/week = 3 weeks At 10mg/week = 1.5 weeks At 15mg/week = 1 week A 10mg vial covers the first month of a standard escalation at 2.5mg/week

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Completion of the total synthesis of (+)-asperazine ( 51 ) was achieved over additional steps including the substrate-controlled hydrogenation (4:1 dr) of intermediate 56 , partial reduction of the resulting oxindole and cyclization to the hexahydropyrroloindoline substructure, followed by condensation and formation of the DKPs