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Therefore, owing to its combined analgesic and pro-healing activities, neurotensin holds a strong potential for incorporation into topical peptide-based therapies targeting chronic wounds

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However, we discovered that these peptides are also functional substrates of transglutaminase (TGM) 2, also called tissue TGM, and that structural disruption of the epidermis was repaired when these tetravalent peptides were applied topically as cross-linking substrates, regardless of possible interaction with MGL1 or MGL2