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The five risks of taking unapproved peptides – Partnership for Safe Medicines
Moreover, while the use of ASNS alone can cause adverse effects such as pancreatitis and thrombosis, its combination with CB-839 effectively mitigates these risks ( 4.3.5 Combination of ammonium metabolism drugs and radiotherapy Excessive ROS production leads to an imbalance between ROS and the cell’s antioxidant defense, resulting in DNA damage, a key mechanism in radiation therapy-mediated tumor treatment (40)
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Studies have also shown that GPX4, an antioxidant enzyme, regulates mitochondria-mediated apoptosis in cancer cells through the modulation of EGR1, functioning as a tumor suppressor in well-differentiated breast cancers and potentially serving as a therapeutic target (74)
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